Chinese Version

Xiaoda Group

Chemical Biology & History of Pharmacy Research

Menu

About
News
People
Publications
Resources（Database）
Gallery

Search for:

Research Overview

In natural science research, we work on genetic code expansion technology and artificial modification of ribosomes. Protein is the material basis of life and is the main bearer of life activities. After a long evolution in nature, the proteins of all living organisms are now mainly composed of 22 natural alpha amino acids. According to the central law, genetic information is translated into relevant coded proteins after being passed from DNA to mRNA. Ribosomes, as sophisticated translation machines, are able to catalyze the condensation of activated aminoacyl-tRNA (α-AA-tRNA) to form peptide bonds as well as peptide chains based on the mRNA coding information, which then undergo certain folding and modification to form polymers of natural α-amino acids (i.e., proteins). We used a directed evolutionary strategy for tool development for the introduction of non-natural amino acids into proteins. We also perform directed evolutionary modification of medicinal proteins.

Also in social science research, we focus on excavating the introduction of Western medicine in China during the Qing Dynasty and the Republic of China, and its spread. The historical process of the development of Western medicine in China has an important relationship with the politics, economy, and culture of China at all stages of history. We examine and analyze them in relation to each other, trying to reveal the development pattern of the history of modern Chinese pharmacy and draw useful lessons from it. We also summarize and discuss the discovery of drugs, and the decay of drugs.

Our long-term goal is to develop the research field of biological ribosome-encoded protein-like polymers at the protein level through chemical biology strategies, by systematically modifying bacteria to encode "proteins containing non-natural amino acids" in vivo. On the other hand, we are actively developing protein-based drugs to overcome emerging and dreaded diseases in the light of history.

Address

Jiangning Campus of China Pharmaceutical University, No. 639 Longmian Avenue, Jiangning District, Nanjing, Jiangsu Province, China

Email：xiaoda.song(at)cpu.edu.cn

备案/许可证编号：苏ICP备2022032509号。 All Rights Reserved. 版权所有

苏公网安备 32011502011665号